In cuprates, electron doping yields a much lower superconducting T_c than hole doping. For recently discovered nickelate superconductors, the analogous doping strategies become more challenging. Consequently, while hole-doped Ruddlesden-Popper (RP) nickelates have been extensively studied, electron-doped RP nickelates remain rarely explored both experimentally and theoretically. Here we fill this gap by systematically investigating the two-orbital bilayer model for three representative systems: bulk La₃Ni₂O₇ at ambient pressure and 15 GPa, and a heterostructure La₃Ni₂O₇:La₃Al₂O₇ that provides a feasible experimental route to electron doping. Using first-principle calculations and large-scale dynamical cluster quantum Monte Carlo simulations, we find that electron doping generically enhances s^±-wave pairing superconductivity (SC) in all three cases, with the heterostructure showing the highest T_c in the underdoped regime. Furthermore, our results suggest an inter-orbital cooperative mechanism that the pairing on the d_(x²-y²) orbital, induced by that on the d_(z²) orbital, plays a vital role in the SC. This work provides the theoretical prediction of enhanced SC in electron-doped RP nickelates and calls for future experimental verification.