In this work, we report the successful synthesis of La₁₋ₓPrₓCo₅ (x = 0.09, 0.21, 0.45) single crystals. Magnetic field-dependent magnetization measurements reveal that Pr substitution induces negligible changes in the magnetic properties of LaCo₅, with the ferromagnetic ordering predominantly governed by the Co sublattices. Remarkably, the doped systems exhibit significant enhancements in the anomalous Nernst effect. At 300 K, the anomalous Nernst thermopower S^A_yx reaches 6.5~μ V/K in La_(0.55)Pr_(0.45)Co₅, corresponding to a ∼ 40 % enhancement compared to the parent compound. This significant improvement can be predominantly attributed to Pr-doping-induced Fermi level modification, which directly leads to a redistribution of Berry curvature across the Fermi surface. This work highlights the effectiveness of Pr doping in boosting the anomalous Nernst effect of La₁₋ₓPrₓCo₅, offering a practical strategy to design advanced materials for room-temperature energy-harvesting technologies and high-efficiency thermal sensing devices.