Cryogenic capacity is a key bottleneck in the scaling of superconducting quantum processors, critically impacted by control wiring. Currently, wiring architectures are often designed following a small set of "best-practice" heuristics, little changed since they emerged for early, small-scale systems, and not rigorously evaluated for wider contexts. Here, we adopt a whole-system numerical modelling approach and present a systematic optimisation for the coaxial wiring design of a superconducting quantum processor. We identify optimised configurations that substantively outperform conventional designs in device temperature, noise burden, qubit capacity and other practical metrics. Importantly, our analysis delivers varied outcomes for different system contexts and operating regimes, illustrating the benefits of a systematic approach when there is no universal solution. Our results evaluate and sometimes challenge conventional wisdom in relation to design factors such as the utility of 0dB attenuators. We also use a wide exploration of cable configurations—directly enabled by our holistic and flexible numerical modelling approach—to develop more rigorously supported general principles for future cryogenic system design, based on a new conceptual framework to describe attenuator cascades that draws on analogies to low-noise amplifier chains. Our approach, design outcomes, and generalised analyses should also be readily applicable to other cryogenic quantum computing platforms. Finally, we support ready adoption of this approach through a web-based graphical tool which streamlines the analysis of the proposed framework under different contexts. Our results illustrate how our approach can help maximise the available computational resources of quantum processors at all system scales.