The QICK (Quantum Instrumentation Control Kit), first introduced in 2022, is a standalone open source control system for quantum information science. Since then, QICK has been migrated to new hardware platforms, expanded its functionality for applications with different types of qubits (superconducting, atomic, ion-trapped, and spin defects), as well as quantum sensors, and quantum networks. QICK is a highly optimized control kit, with a library of functions that can be used for more than one application. In particular, the software and firmware are customized to minimize latency and maximize control performance and throughput. In this white paper, we describe hardware details and performance of the QICK Box. The QICK Box features up to 16 outputs, up to 8 inputs, and 8 20-bit DC biases. Modular output and input daughtercards give the choice of signal chains optimized for fast DC-coupled signals or RF signals up to 10 GHz. Power levels, step attenuation, and bandpass filtering are controlled by software. We demonstrate the system's performance through single-shot readout measurements of a six-transmon device at the Quantum Underground Instrumentation Experimental Testbed (QUIET) at Fermilab, achieving (91.7 +/- 0.4)% readout fidelity limited by T1 decay during the readout. The single shot readout signal-to-noise ratio (SNR) is 4.4 +/- 0.1 without a quantum amplifier, confirming that the QICK Box is suitable for high-fidelity quantum control and measurement applications. Advances in firmware and software will be described in a separate paper.