Chiral anomaly in topological materials manifests as negative longitudinal magnetoresistance, yet the tunability and evolution of this effect remain elusive. Here we show that doped tellurium serves as a versatile platform to realize a giant negative longitudinal magnetoresistance that is highly tunable via the Fermi level and magnetic field. By moving the Fermi level towards the Weyl point, we observe a pronounced enhancement of negative magnetoresistance, which arises from chiral anomaly and robustly persists up to ambient temperature. Beyond the quantum limit, the system exhibits positive linear magnetoconductance, serving as a compelling transport signature of the chiral anomaly in the lowest Landau level. Notably, in the extreme quantum limit at cryogenic temperatures, the magnetoresistance undergoes a dramatic reversal from negative to positive. This reversal points to a potential field-induced phase transition into a collective electronic state driven by enhanced electron-electron interactions. Our findings provide valuable insights into the unconventional chiral transport and emergent correlated quantum states under extreme magnetic fields.